Selected ingredients in Cortisen® have been studied individually in relation to stress, sleep, relaxation, cognitive function and the physiological stress response. The studies below relate to the individual ingredients and should not be interpreted as clinical evidence for the finished Cortisen® product.
Ingredient study
Holixer™
- Randomized
- Double-blind
- Placebo-controlled
- 100 adults with elevated perceived stress
- 250 mg/day
- 8 weeks
The study assessed perceived stress, sleep and physiological stress-response measures, including cortisol.
Lopresti AL, Smith SJ, Metse AP, Drummond PD. A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer™) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. 2022;9:965130. DOI: 10.3389/fnut.2022.965130
Ingredient study
Lactium®
- Randomized
- Double-blind
- Placebo-controlled
- Crossover
- 63 women
- 150 mg/day
- 30 days
The study evaluated changes in stress-related symptoms in women receiving αS1-casein hydrolysate.
Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, et al. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. European Journal of Clinical Nutrition. 2007;61(4):536–541. DOI: 10.1038/sj.ejcn.1602553
Ingredient study
L-theanine
- Randomized controlled trial
- Healthy adults
- 200 mg/day
- 4 weeks
The study investigated stress-related symptoms, sleep-related outcomes and cognitive functions in healthy adults.
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Nutrients. 2019;11(10):2362. DOI: 10.3390/nu11102362
References
- 1.
Lopresti AL, Smith SJ, Metse AP, Drummond PD. A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (Holixer™) on stress, mood, and sleep in adults experiencing stress. Frontiers in Nutrition. 2022;9:965130.
- 2.
Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, et al. Efficacy of αs1-casein hydrolysate on stress-related symptoms in women. European Journal of Clinical Nutrition. 2007;61(4):536–541.
- 3.
Saint-Hilaire Z, Messaoudi M, Desor D, Kobayashi T. Effects of a bovine alpha S1-casein tryptic hydrolysate (CTH) on sleep disorder in Japanese general population. The Open Sleep Journal. 2009;2:26–32.
- 4.
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Nutrients. 2019;11(10):2362.
- 5.
Evans M, McDonald AC, Xiong L, Crowley DC, Guthrie N. A randomized, triple-blind, placebo-controlled, crossover study to investigate the efficacy of a single dose of AlphaWave® L-theanine on stress in a healthy adult population. Neurology and Therapy. 2021;10(2):1061–1078.
Scientific references relate to the individual ingredients studied. Product composition, classification, approved claims and instructions may vary by market. The approved local product information remains authoritative.
